Coronary disease & ACSCohort study
Microvascular resistance reserve: impact on health status and myocardial perfusion after revascularization in chronic coronary syndrome
- Prospective cohort study
Authors' conclusion
In patients with moderate coronary stenoses, MRR seems to predict the symptomatic and perfusion benefit of revascularization.
Study context
- Population
- Consecutive patients with stable chest pain and moderate (30%-90% diameter) stenoses on invasive coronary angiography
- Participants
- 222 patients
- Exposure
- Microvascular resistance reserve (MRR) and revascularization status
- Outcome
- Freedom from angina
- Follow-up
- follow-up
Main finding
As reported in the abstract
Odds ratio
0.860
95% CI 0.740–0.987
MRR
OR 0.860 (95% CI 0.740–0.987)
- Freedom from angina
- 38/173
Observational data: associations, not effects.
Secondary outcomes
Seattle Angina Questionnaire (SAQ) angina frequency score
| Comparison | mean difference (CI) | |
|---|---|---|
| Normal MRR, no revascularization | 8.5 (3.07–13.11) | |
| Abnormal MRR, revascularization | 13.5 (2.82–23.16) | |
| −100102030Difference (linear scale) |
SAQ physical limitation score
| Comparison | mean difference (CI) | |
|---|---|---|
| Normal MRR, no revascularization | 9.7 (4.79–11.93) | |
| Abnormal MRR, revascularization | 8.7 (0.53–13.88) | |
| −1001020Difference (linear scale) |
SAQ summary score
| Comparison | mean difference (CI) | |
|---|---|---|
| Normal MRR, no revascularization | 9.3 (5.18–12.50) | |
| Abnormal MRR, revascularization | 10.8 (2.51–17.28) | |
| −1001020Difference (linear scale) |
Myocardial perfusion (PET)
- Only patients with abnormal MRR who underwent revascularization had improved myocardial perfusion
Original publication
Microvascular resistance reserve: impact on health status and myocardial perfusion after revascularization in chronic coronary syndrome. Eur Heart J. Published 1 September 2024. doi:10.1093/eurheartj/ehae604
Summarised from the published abstract; every number is checked against it