Randomised controlled trial
Minithoracotomy vs Conventional Sternotomy for Mitral Valve Repair
- Randomised controlled trial
- pragmatic
- multicentre
- superiority
- 10 tertiary care institutions in the UK
Authors' conclusion
Minithoracotomy is not superior to sternotomy in recovery of physical function at 12 weeks. Minithoracotomy achieves high rates and quality of valve repair and has similar safety outcomes at 1 year to sternotomy.
Study context
- Population
- Adults with degenerative mitral regurgitation undergoing mitral valve repair surgery294 reported primary outcome
- Participants
- 330 adults
- Comparison
- Minithoracotomy vs sternotomy mitral valve repair
- Minithoracotomyn = 166
- Sternotomyn = 164reference
- Primary endpoint
- Change from baseline in SF-36 v2 physical functioning scale, assessed by a masked independent researcher
- Follow-up
- 12 weeks after surgery
Primary result
As reported in the abstract
Change from baseline in SF-36 physical function T score · 12 weeks
Mean between-group difference in change in SF-36 physical function T score (direction of subtraction not stated)
0.68 (95% CI, −1.89 to 3.26)
Secondary outcomes
Composite of death, repeat mitral valve surgery or HF hospitalization · up to 1 year
- Composite of death, repeat mitral valve surgery or HF hospitalization: denominators 166 and 163
Valve repair rates
- Valve repair rates (≈ 96%) similar in both groups
Mitral regurgitation none or mild on echocardiography · up to 1 year
- None or mild MR in 92% of participants, no difference between groups
Original publication
Minithoracotomy vs Conventional Sternotomy for Mitral Valve Repair. JAMA. Published 13 June 2023. doi:10.1001/jama.2023.7800
Summarised from the published abstract; every number is checked against it