Valvular & structural heart diseaseCohort study
Mitral Annular Calcification-Related Mitral Stenosis
- Retrospective cohort study
- multicentre
- 11 Japanese centres
Authors' conclusion
The prognosis of MAC-related mitral stenosis was poor, with a 5-year survival of 57%, mainly driven by noncardiac mortality in calcific mitral stenosis. Severity of mitral stenosis was one of the independent predictors in this high-risk population.
Study context
- Population
- Adults with mitral annular calcification (MAC) and transmitral mean gradient ≥5 mm Hg on echocardiography, 2016–2017 (JAMAC)
- Participants
- 264 adults
- Exposure
- Calcific vs rheumatic MAC-related mitral stenosis
- Calcific mitral stenosisn = 201
- Rheumatic mitral stenosisn = 63reference
- Outcome
- All-cause mortality
- Follow-up
- 5 years
Main finding
As reported in the abstract
Adjusted hazard ratio
1.56
95% CI 1.03–2.38
MVA vs Rheumatic mitral stenosis
adjusted HR 1.56 (95% CI 1.03–2.38)
- Five-year survival
- 57%
Observational data: associations, not effects.
Secondary outcomes
Cardiac and noncardiac death · 5 years
Cardiac death
Noncardiac death
- Cardiac and noncardiac death — Overall cardiac mortality
- 16%
- Cardiac and noncardiac death — Overall noncardiac mortality
- 24%
Original publication
Mitral Annular Calcification-Related Mitral Stenosis. J Am Coll Cardiol. Published 4 March 2026. doi:10.1016/j.jacc.2025.12.004
Summarised from the published abstract; every number is checked against it