Valvular & structural heart disease
Mitral Annular Calcification-Related Mitral Stenosis: 5-Year Outcomes and Prognostic Determinants in the JAMAC Study
Main finding · All-cause mortalityResult — go to the resultAdjusted hazard ratio 1.56 95% CI 1.03–2.38Authors' conclusion
The prognosis of MAC-related mitral stenosis was poor, with a 5-year survival of 57%, mainly driven by noncardiac mortality in calcific mitral stenosis. Severity of mitral stenosis was one of the independent predictors in this high-risk population.
Study context
- Population
- Adults with mitral annular calcification (MAC) and transmitral mean gradient ≥5 mm Hg on echocardiography, 2016–2017 (JAMAC)
- Participants
- 264 adults
- Exposure
- Calcific vs rheumatic MAC-related mitral stenosis
- Calcific mitral stenosisn = 201
- Rheumatic mitral stenosisn = 63reference
- Outcome
- All-cause mortality
- Follow-up
- 5 years
Methodological detailsmulticentre, 11 Japanese centres
- Multicentre
- 11 Japanese centres
Main finding
As reported in the abstract
Adjusted hazard ratio
1.56
95% CI 1.03–2.38
Calcificvs rheumatic MAC-related mitral stenosis
adjusted HR 1.56 (95% CI 1.03–2.38)
- Five-year survival
- 57%
Observational data: associations, not effects.
Secondary outcomes
Cardiac and noncardiac death · 5 years
Cardiac death
Noncardiac death
- Cardiac and noncardiac death — Overall cardiac mortality
- 16%
- Cardiac and noncardiac death — Overall noncardiac mortality
- 24%
Original publication
Mitral Annular Calcification-Related Mitral Stenosis: 5-Year Outcomes and Prognostic Determinants in the JAMAC Study. J Am Coll Cardiol. Published 4 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →