Arrhythmias & electrophysiologyCohort study
Mitral annular disjunction and mitral valve prolapse: long-term risk of ventricular arrhythmias after surgery
- Retrospective cohort study
- single-centre
Authors' conclusion
Mitral annular disjunction in patients with MVP and MR was associated with a three-fold increased long-term risk of VA post-mitral valve surgery, despite anatomical correction of MAD.
Study context
- Population
- Patients with mitral valve prolapse (MVP) and moderate or severe degenerative mitral regurgitation (MR) undergoing mitral valve surgery (repair or replacement), Karolinska University Hospital, 2010–22
- Participants
- 599 patients
- Exposure
- Pre-operative mitral annular disjunction (MAD) vs no MAD
- MADn = 96
- Outcome
- Ventricular arrhythmias (VA) (hospitalizations, outpatient visits or ablation for confirmed sustained or non-sustained VT, or high burden of premature ventricular complexes)
- Follow-up
- Median 5.4 (IQR 2.8-7.5) years
Main finding
VA
Hazard ratio
3.33
95% CI 1.37–8.08
MAD vs No MAD
HR 3.33 (95% CI 1.37–8.08)
As reported in the abstract
Observational data: associations, not effects.
Further findings
- MAD length
- 8.0 · median · IQR 5.0–10.0 · mm
Original publication
Mitral annular disjunction and mitral valve prolapse: long-term risk of ventricular arrhythmias after surgery. Eur Heart J. Published 15 April 2025. doi:10.1093/eurheartj/ehaf195
Summarised from the published abstract; every number is checked against it