Mitral Regurgitation and Severe Aortic Stenosis: Clinical Characteristics, Prognostic Impact, and Response to TAVR: Insights From Egnite Data

doi:10.1161/circinterventions.126.016578

Valvular & structural heart diseaseCohort study

Mitral Regurgitation and Severe Aortic Stenosis: Clinical Characteristics, Prognostic Impact, and Response to Transcatheter Aortic Valve Replacement (TAVR): Insights From Egnite Data

Circ Cardiovasc IntervPublished 11 Sep 2026

Retrospective analysis of a multicentre echocardiography database
43 US institutions
Egnite Database

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Authors' conclusion

Patients with concurrent MR and AS exhibit substantially higher mortality yet have high rates of undertreatment throughout the duration of follow-up. TAVR alone significantly improves MR in most patients.

Study context

Population: Adults (aged ≥18 years) with severe aortic stenosis (AS) and moderate or greater mitral regurgitation (MR)cohort with severe AS and moderate or greater MR, identified from 2,992,362 patients undergoing 5,245,904 echocardiograms
Participants: 36,402 adults

Exposure: untreated vs TAVR alone vs surgery or other transcatheter interventions
Outcome: All-cause mortality in untreated patients, by MR severity
Follow-up: 2 years

Main finding

As reported in the abstract

AS with less than moderate MR (untreated)36.8%

AS with moderate MR (untreated)57.3%

AS with moderate-to-severe or severe MR (untreated)65.5%

Observational data: associations, not effects.

Further findings

Treatment distribution

untreated52.0%

TAVR alone36.5%

surgery or other transcatheter interventions11.5%

Outcome	undertreatment	P value
Undertreatment, AS with significant MR versus without · more frequent in patients with AS and significant MR	64.5% versus 49.9%	P < 0.001

Treatment distribution — mean age: 78.2 years
Treatment distribution — male: 54.6%

Improvement in MR after TAVR alone (patients with follow-up MR data) · 45 days post-TAVR

demonstrated improvement in MR: 77.5%

visualized using Sankey diagrams

Original publication

Mitral Regurgitation and Severe Aortic Stenosis: Clinical Characteristics, Prognostic Impact, and Response to TAVR: Insights From Egnite Data. Circ Cardiovasc Interv. Published 11 September 2026. doi:10.1161/circinterventions.126.016578

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Summarised from the published abstract; every number is checked against it