Valvular & structural heart disease
Mitral Regurgitation and Severe Aortic Stenosis: Clinical Characteristics, Prognostic Impact, and Response to Transcatheter Aortic Valve Replacement (TAVR): Insights From Egnite Data
Authors' conclusion
Patients with concurrent MR and AS exhibit substantially higher mortality yet have high rates of undertreatment throughout the duration of follow-up. TAVR alone significantly improves MR in most patients.
Study context
- Population
- Adults (aged ≥18 years) with severe aortic stenosis (AS) and moderate or greater mitral regurgitation (MR)cohort with severe AS and moderate or greater MR, identified from 2,992,362 patients undergoing 5,245,904 echocardiograms
- Participants
- 36,402 adults
- Exposure
- Untreated vs TAVR alone vs surgery or other transcatheter interventions
- Outcome
- All-cause mortality in untreated patients, by MR severity
- Follow-up
- 2 years
Methodological details43 US institutions, Egnite Database
- 43 US institutions
- Egnite Database
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Treatment distribution
| Outcome | Undertreatment | P value |
|---|---|---|
| Undertreatment, AS with significant MR versus withoutMore frequent in patients with AS and significant MR | 64.5% versus 49.9% | P < 0.001 |
- Treatment distribution — mean age
- 78.2 years
- Treatment distribution — male
- 54.6%
Improvement in MR after TAVR alone (patients with follow-up MR data) · 45 days post-TAVR
- Demonstrated improvement in MR
- 77.5%
- Visualized using Sankey diagrams
Original publication
Mitral Regurgitation and Severe Aortic Stenosis: Clinical Characteristics, Prognostic Impact, and Response to TAVR: Insights From Egnite Data. Circ Cardiovasc Interv. Published 11 September 2026. doi:10.
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