Valvular & structural heart diseaseCohort study
Mitral transcatheter edge-to-edge repair vs. isolated mitral surgery for severe mitral regurgitation: a French nationwide study
- Retrospective cohort study
- propensity-score matched
- nationwide
Authors' conclusion
Our results suggest that TEER for severe mitral regurgitation was associated with lower cardiovascular mortality than mitral surgery at long-term follow-up. Pacemaker implantation and stroke were less frequently observed after TEER.
Study context
- Population
- Patients treated for mitral regurgitation, French administrative hospital discharge database, 2012–2022matched cohort, 2160 per arm
- Participants
- 57,030 patients
- Exposure
- Mitral transcatheter edge-to-edge repair (TEER) vs isolated mitral valve surgery
- TEERn = 2,160
- Mitral surgeryn = 2,160reference
Main finding
CV death · 3-year follow-up
Hazard ratio
0.685
95% CI 0.563–0.832
P = 0.0001
TEER vs Mitral surgery
HR 0.685 (95% CI 0.563–0.832); P = 0.0001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Non-CV death · 3-year follow-up · more frequent after TEER | 1.562 (1.238–1.971) | P = 0.0002 | |
| All-cause death · 3-year follow-up | 0.967 (0.835–1.118) | P = 0.65 | |
| 0.512Hazard ratio (log scale) |
Pacemaker implantation, stroke · 3-year follow-up
- Significantly lower incidence with TEER
Recurrent pulmonary oedema, cardiac arrest · 3-year follow-up
- More frequent after TEER
Endocarditis, major bleeding, AF, MI · 3-year follow-up
- No significant differences between the two groups
Original publication
Mitral transcatheter edge-to-edge repair vs. isolated mitral surgery for severe mitral regurgitation: a French nationwide study. Eur Heart J. Published 19 January 2024. doi:10.1093/eurheartj/ehae046
Summarised from the published abstract; every number is checked against it