Mitral valve replacement or repair and long-term risk of infective endocarditis: a Danish nationwide study

doi:10.1093/eurheartj/ehaf342

Cardio-oncology & otherCohort study

Mitral valve replacement or repair and long-term risk of infective endocarditis: a Danish nationwide study

Eur Heart JPublished 11 Jul 2025

Nationwide registry-based cohort study
Danish nationwide registries
multivariable-adjusted

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Authors' conclusion

In this nationwide study, MV replacement was associated with a 3.5-fold increased 10-year IE rate, whereas MV repair was not significantly associated with IE, compared with patients at moderate risk of IE.

Study context

Population: Patients undergoing isolated mitral valve (MV) replacement or repair and patients at moderate risk of infective endocarditis (IE), Denmark 2000–2020
Participants: 1,220 / 3,239 / 209,517

Exposure: MV replacement or MV repair vs moderate risk of IE
MV replacementn = 1,220
MV repairn = 3,239
Moderate-riskn = 209,517reference
Outcome: First-time infective endocarditis (IE)
Follow-up: 10 years

Main finding

As reported in the abstract

10-year cumulative incidence of IE

MV replacement6.1%cumulative incidence · 95% CI 4.8%–7.7%

MV repair1.6%cumulative incidence · 95% CI 1.1%–2.1%

Moderate-risk1.7%cumulative incidence · 95% CI 1.6%–1.7%

after multivariable adjustment

Each group vs moderate-riskHazard ratio (95% CI)

MV replacement

3.52(2.73–4.52)

MV repair

0.76(0.56–1.04)

Observational data: associations, not effects.

Original publication

Mitral valve replacement or repair and long-term risk of infective endocarditis: a Danish nationwide study. Eur Heart J. Published 11 July 2025. doi:10.1093/eurheartj/ehaf342

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Summarised from the published abstract; every number is checked against it