Acute cardiac care & resuscitationCohort study
Modifiable Mechanical Ventilation Targets Are Associated With Improved Survival in Ventilated Venoarterial Extracorporeal Life Support (VA-ECLS) Patients
- Retrospective registry cohort study
- multivariable-adjusted
Authors' conclusion
LPPV is associated with improved outcomes in CS patients on VA-ECLS requiring MV.
Study context
- Population
- Patients with cardiogenic shock on VA-ECLS and mechanical ventilation, ELSO registry, 2009–2019
- Participants
- 2,226 patients
- Exposure
- LPPV vs no LPPV
- LPPVn = 1,904
- Outcome
- Survival to discharge
Main finding
As reported in the abstract
Adjusted odds ratio
1.69
95% CI 1.21–2.37
P = 0.0021
By group
LPPV vs no-LPPV
adjusted OR 1.69 (95% CI 1.21–2.37); P = 0.0021
Observational data: associations, not effects.
Further findings
Ventilator pressures at 24 h, survivors to discharge vs non-survivors
- Median peak inspiratory pressure lower in survivors: 22 vs 24 cm H2O
- P < 0.001
- Median dynamic driving pressure (DDP) lower in survivors: 14.5 vs 16 cm H2O
- P < 0.001
Original publication
Modifiable Mechanical Ventilation Targets Are Associated With Improved Survival in Ventilated VA-ECLS Patients. JACC Heart Fail. Published 10 May 2023. doi:10.1016/j.jchf.2023.03.023
Summarised from the published abstract; every number is checked against it