Heart failure & cardiomyopathiesCohort study
Monitoring of Myocardial Involvement in Early Arrhythmogenic Right Ventricular Cardiomyopathy Across the Age Spectrum
- Longitudinal cohort study
- computational modelling (Digital Twins)
Authors' conclusion
Disease progression was similar in all age groups, and sustained VA also occurred in patients aged >50 years without overt ARVC phenotype at first evaluation.
Study context
- Population
- Patients with early-stage arrhythmogenic right ventricular cardiomyopathy (ARVC) and genotype-positive relatives without overt structural disease and VA at first evaluation313 echocardiographic assessments
- Participants
- 82 patients
- Exposure
- Age <30 years vs 30 to 50 years vs ≥50 years
- Outcome
- Myocardial disease progression by longitudinal biventricular deformation
Main finding
As reported in the abstract
Longitudinal strain progression · 6.7 ± 3.3 years of follow-up
LV global longitudinal strain deterioration, similar in all age groups (%-point per year)
0.1 (95% CI: 0.05-0.15)
RV lateral wall longitudinal strain worsening, all age groups (%-point per year)
0.6 (95% CI: 0.46-0.70)
Observational data: associations, not effects.
Further findings
Digital Twin RV lateral wall
- Local differences in myocardial contractility, compliance and activation delay
Safety
VA during follow-up
- Patients with VA during follow-up
- 6
Original publication
Monitoring of Myocardial Involvement in Early Arrhythmogenic Right Ventricular Cardiomyopathy Across the Age Spectrum. J Am Coll Cardiol. Published 29 August 2023. doi:10.1016/j.jacc.2023.05.065
Summarised from the published abstract; every number is checked against it