Coronary disease & ACSSecondary analysis
Mortality After High-Risk Myocardial Infarction Over the Last 20 Years: Insights from the VALIANT and PARADISE-MI Trials
- Secondary analysis of the VALIANT and PARADISE-MI randomised trials
Authors' conclusion
Cardiovascular mortality following high-risk myocardial infarction has significantly declined over time, while the risk for non-CV death has remained unchanged. This improvement is partially attributable to advancements in CV care, particularly the use of PCI.
Study context
- Population
- High-risk MI survivors enrolled in clinical trials
- Participants
- 5,661 vs 9,617
- Comparison
- PARADISE-MI vs VALIANT participants
- PARADISE-MIn = 5,661
- VALIANTn = 9,617reference
- Primary endpoint
- All-cause mortality
Primary result
As reported in the abstract
PARADISE-MI vs VALIANTEstimate (95% CI)
unadjusted
HR 0.41(0.37–0.46)
adjusted for clinical variables
adjusted HR 0.68(0.58–0.80)
Further findings
Cardiovascular (CV) death
- Similar results to all-cause mortality
Non-CV mortality
- No significant between-trial differences
Original publication
Mortality After High-Risk Myocardial Infarction Over the Last 20 Years: Insights from the VALIANT and PARADISE-MI Trials. Eur J Heart Fail. Published 18 December 2024. doi:10.1002/ejhf.3557
Summarised from the published abstract; every number is checked against it