Mortality After Non–ST-Segment Elevation Myocardial Infarction: Impact of Left Ventricular Function and Coronary Artery Disease
Main finding · 5-year mortalityResult — go to the resultAdjusted hazard ratio 3.05 95% CI 2.51–3.70Authors' conclusion
In patients with NSTEMI, the combined information on LVEF and the extent of obstructive CAD was associated with an increasing 5-year mortality. A comparison with a matched general population confirmed the findings.
Study context
- Population
- Patients with first-time NSTEMI and obstructive coronary artery disease (CAD) referred to coronary angiography, 2010–2021
- Participants
- 8,770 patients
- Exposure
- Left ventricular ejection fraction (LVEF) category and extent of obstructive CAD
- Outcome
- Mortality
- Follow-up
- 5 years
Methodological detailsWestern Denmark Heart Registry, sex- and age-matched general population comparison
- Western Denmark Heart Registry
- Sex- and age-matched general population comparison
Main finding
5-year mortality
Adjusted hazard ratio
3.05
95% CI 2.51–3.70
By group
LVEF ≤40% and 3VDvs LVEF >50% and 1VD
adjusted HR 3.05 (95% CI 2.51–3.70)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Excess mortality vs matched general population
- LVEF ≤40% and 3VD: higher absolute mortality than matched general population
- 24%
- Sex- and age-matched general population cohort
Original publication
Mortality After Non–ST-Segment Elevation Myocardial Infarction: Impact of Left Ventricular Function and Coronary Artery Disease. JACC Adv. Published 16 September 2025. doi:10.
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