Heart failure & cardiomyopathiesMeta-analysis
Mortality and heart failure hospitalizations in heart failure with preserved ejection fraction compared to heart failure with reduced ejection fraction: a systematic review and meta-analysis
- systematic review and meta-analysis
- random-effects models
Authors' conclusion
HFpEF patients experience lower mortality and hospitalization risks than HFrEF patients, even after adjustment for confounders. However, high absolute event rates in HFpEF highlight the need for effective treatment strategies to improve outcomes. PROSPERO registration ID: CRD42024619499.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF) or heart failure with reduced ejection fraction (HFrEF)101 studies
- Comparison
- HFpEF vs HFrEF
Pooled result
As reported in the abstract
All-cause mortality
Each group vs HFrEFEstimate (95% CI)P value
HFpEF
RR 0.78(0.69–0.88)
P < 0.001HFpEF
adjusted HR 0.71(0.62–0.80)
P < 0.001Further pooled results
per 1000 patient-years (PY)
| Outcome | HFpEF | HFrEF | Estimate | P value | |
|---|---|---|---|---|---|
| CV mortality | 73 | 110 | RR 0.64 (95% CI 0.53–0.79) | P < 0.001 | |
| CV mortality | adjusted HR 0.65 (95% CI 0.56–0.75) | P < 0.001 | |||
| HF hospitalizations | 171 | 225 | RR 0.75 (95% CI 0.63–0.91) | P = 0.003 | |
| HF hospitalizations | adjusted HR 0.87 (95% CI 0.78–0.98) | P = 0.02 | |||
| 0.512Ratio (log scale) |
Original publication
Mortality and heart failure hospitalizations in heart failure with preserved ejection fraction compared to heart failure with reduced ejection fraction: a systematic review and meta-analysis. ESC Heart Fail. Published 16 January 2026. doi:10.1093/eschf/xvag026
Summarised from the published abstract; every number is checked against it