Heart failure & cardiomyopathies
Mortality in Patients With Hodgkin Lymphoma and Heart Failure: A Swedish Population-Based Study
Authors' conclusion
cHL was associated with higher all-cause mortality following HF diagnosis. CV-specific mortality was significantly higher for patients with HF ≥10 years after cHL, possibly highlighting the impact of late treatment toxicity, although careful interpretation is warranted given the strong competing risk of lymphoma-related deaths.
Study context
- Population
- Patients with classical Hodgkin lymphoma (cHL) and subsequent heart failure (HF), and comparators with HF, 2000 to 2022
- Participants
- 257 vs 514
- Comparison
- All-cause mortality following HF diagnosis between patients with prior cHL and comparators
- cHLn = 257
- Comparatorsn = 514reference
- Outcome
- Deaths
- Follow-up
- Median 2.5 years for cHL and 3.3 years for comparators
Methodological detailsmatched 1:2 on sex, birth year, year of HF, and contact type (inpatient/outpatient), flexible parametric survival models adjusted for matching variables
- Matched 1:2 on sex, birth year, year of HF, and contact type (inpatient/outpatient)
- Flexible parametric survival models adjusted for matching variables
Main finding
As reported in the abstract
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| All-cause mortalityHigher with prior cHL | 1.81 (1.44–2.26) | |
| CV-specific mortality (explorative outcome)Overall; did not differ | 1.17 (0.78–1.75) | |
| CV-specific mortality (explorative outcome)Patients with HF ≥10 years after cHL | 3.13 (1.71–5.73) | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | cHL | Comparators |
|---|---|---|
| Cause of death | ||
| Lymphoma-related death | 40% | — not stated in the abstract |
| CV death | — not stated in the abstract | 42% |
— not stated in the abstract
Original publication
Mortality in Patients With Hodgkin Lymphoma and Heart Failure: A Swedish Population-Based Study. JACC Adv. Published 22 July 2026. doi:10.
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