Heart failure & cardiomyopathies
Mortality reduction with implanted defibrillator for primary prevention of sudden death after Myocardial Infarction: temporal trends in the PROFID study
Authors' conclusion
In this analysis including a large cohort of post-myocardial infarction patients with reduced LVEF, the estimated mortality reduction associated with primary prevention ICD implantation progressively decreased over time.
Study context
- Population
- Post-MI patients with left ventricular ejection fraction (LVEF) ≤35%, PROFID pooled cohort, inclusion 1995–202012,097 deaths
- Participants
- 32,214 patients
- Exposure
- Primary prevention implantable cardioverter-defibrillator (ICD) vs no ICD, by time period
- ICDn = 7,477
- Non-ICDn = 24,737reference
- Outcome
- All-cause mortality
- Follow-up
- Mean 43.7 months
Methodological detailsindividual participant data, propensity-score overlap weighting, prespecified time periods
- Individual participant data
- Propensity-score overlap weighting
- Prespecified time periods
Main finding
As reported in the abstract
All-cause mortality by inclusion period
ICD vs Non-ICDHazard ratio (95% CI)P value
1995-2004
0.54(0.47–0.62)
P < 0.0012005-2014
0.67(0.62–0.72)
P < 0.0012015-2020
0.89(0.73–1.07)
P = 0.221Observational data: associations, not effects.
Original publication
Mortality reduction with implanted defibrillator for primary prevention of sudden death after Myocardial Infarction: temporal trends in the PROFID study. Eur Heart J. Published 28 August 2026. doi:10.
Summarised from the published abstract; every number is checked against it