Prevention & lipidsCohort study
Moving beyond LDL cholesterol: apolipoprotein B and lipoprotein(a) for sex-specific risk assessment of aortic stenosis in the UK Biobank
- Prospective cohort study
- sex-stratified
Authors' conclusion
ApoB may substitute for LDL-c as the primary particle-burden marker, whereas Lp(a) should be incorporated as an independent sex-specific risk enhancer in AS risk assessment.
Study context
- Population
- UK Biobank participants free of baseline CVD (mean age 56.1±8.07 years; 55.74% female)
- Participants
- 365,771 participants
- Exposure
- Lipid traits and others) and incident aortic stenosis (AS) and AR, by sex
- Outcome
- Incident AS and AR
- Follow-up
- Median 13.8 years
Main finding
As reported in the abstract
Incident AS
Incident AS cases
3118
Total cholesterol, apolipoprotein B (apoB), LDL-C, non-HDL-C and Lp(a) each independently associated with higher AS risk in both sexes
all P < 0.01
Lp(a) conferred additional sex-specific effect
P for interaction = 0.004
Observational data: associations, not effects.
Further findings
Incident AR · median follow-up 13.8 years
- Incident AR cases
- 1239
- No lipid trait was associated with AR
Hierarchical clustering of lipid traits
- Three clusters in both sexes: apoB-containing, apolipoprotein A-containing, Lp(a) independent branch
Original publication
Moving beyond LDL cholesterol: apolipoprotein B and lipoprotein(a) for sex-specific risk assessment of aortic stenosis in the UK Biobank. Eur J Prev Cardiol. Published 8 May 2026. doi:10.1093/eurjpc/zwag257
Summarised from the published abstract; every number is checked against it