Arrhythmias & electrophysiologyResearch article
MRI-guided multipolar functional substrate mapping identifies intramural conduction corridors: The TRAMPOLINE VT study
- Clinical trial
- coregistered magnetic resonance imaging scar models
Authors' conclusion
Functional mapping improved the identification of delayed conduction for all catheters, and MP annotation enhanced the delineation of intramural conduction corridors via the endocardial surface.
Study context
- Population
- Patients with ischemic cardiomyopathy undergoing ventricular tachycardia ablationBP group 12 · multipolar (MP) group 6
- Participants
- 18 patients
- Comparison
- SE mapping vs sinus rhythm (SR); MP annotation vs BP annotation
- BP groupn = 12
- MP groupn = 6
Main finding
As reported in the abstract
LP density over endocardial substrate, SE vs SR
long-spline OCTARAY
from 6% to 14%
Oct-S
from 1% to 32%
OPTRELL
from 21% to 45%
P < 0.001
Further findings
| Outcome | Values | Estimate | P value |
|---|---|---|---|
| LPs identified, MP vs BP annotation — MP annotation vs BP annotation · endocardial corridors | 27% vs 9% | P < 0.001 | |
| LPs identified, MP vs BP annotation — MP annotation vs BP annotation · mid-myocardial corridors | 41% vs 12% | P < 0.001 | |
| CV over mid-myocardial corridors, MP annotation · CV slowed over mid-myocardial corridors | 18 cm/s vs 39 cm/s cm/s | P < 0.001 | |
| Substrate-adjacent conduction vector heterogeneity (AR) | functional MP mapping AR 0.59 · SR BP mapping AR 0.76 |
- Substrate-adjacent conduction vector heterogeneity (anisotropic ratio (AR)): greatest with functional MP mapping, smallest with SR BP mapping (P < .001)
Median local activation time and conduction velocity (CV) by corridor depth, BP annotation
- similar when stratified by corridor depth
- P > 0.1
Local activation time by depth, MP annotation
ms
- delayed per 10% increase in depth in SR
- 12
- delayed per 10% increase in depth after SE
- 7
- P < .001
Original publication
MRI-guided multipolar functional substrate mapping identifies intramural conduction corridors: The TRAMPOLINE VT study. Heart Rhythm. Published 25 August 2026. doi:10.1016/j.hrthm.2026.08.025
Summarised from the published abstract; every number is checked against it