Heart failure & cardiomyopathies
Multi-Ethnic Study of Atherosclerosis Early Heart Failure Study: Rationale, Design, and Baseline Characteristics
Authors' conclusion
The MESA Early HF study is a key resource for cardiovascular researchers who are interested in improving the epidemiological and phenotypic characterization of early HF.
Study context
- Population
- Older adults in the MESA cohort at exam 6, 2016–2018
- Participants
- 3,285 adults · 6 field centres
- Outcome
- Baseline characteristics and feasibility
Methodological detailsdesign and baseline characteristics, population-based, multicentre (6 field centres), multi-ethnic, Between 2016 and 2018: speckle-tracking echocardiography with passive leg raise, KCCQ, 6-minute walk test, arterial stiffness, proteomics incl. NT-proBNP
- Design and baseline characteristics
- Population-based
- Multicentre (6 field centres)
- Multi-ethnic
- Between 2016 and 2018: speckle-tracking echocardiography with passive leg raise, KCCQ, 6-minute walk test, arterial stiffness, proteomics incl. NT-proBNP
Main finding
As reported in the abstract
- Median age, years (25th–75th percentile 67-81)
- 73
- Female
- 53.2%
- Black
- 25.6%
- Chinese
- 12.8%
- White
- 40.0%
- Hypertension
- 61.9%
- Former or current smoking
- 53.7%
- Obesity
- 34.8%
- DM
- 24.7%
- CKD
- 22%
- Overt CVD, from heart failure (HF) to AF
- 2.1% to 13.6%
- Underwent proteomics
- 96%
- Underwent Kansas City Cardiomyopathy Questionnaire
- 94%
- Underwent speckle-tracking echocardiography with passive leg raise
- 93%
- Underwent arterial stiffness exam
- 82%
- Underwent 6-minute walk test
- 77%
- Feasibility of resting speckle-tracking echocardiography across cardiac chambers
- 87%-99%
- Feasibility of passive leg raise Doppler/speckle-tracking echocardiography
- >84%
- Unique echocardiographic indices measured
- 120
Observational data: associations, not effects.
Original publication
Multi-Ethnic Study of Atherosclerosis Early Heart Failure Study: Rationale, Design, and Baseline Characteristics. Circ Heart Fail. Published 8 March 2024. doi:10.
Summarised from the published abstract; every number is checked against it