Heart failure & cardiomyopathies
Multicenter Study of Survival Benefit of Cardiac Resynchronization Therapy in Pediatric and Congenital Heart Disease
Authors' conclusion
In pediatric and CHD patients with symptomatic systolic heart failure and electrical dyssynchrony, CRT was associated with improved heart transplantation-free survival.
Study context
- Population
- Patients <21 years or with congenital heart disease (CHD), systemic ventricular EF <45%, symptomatic HF and significant electrical dyssynchrony (QRS z score >3 or single-site ventricular pacing >40%)139 matched pairs
- Participants
- 167 vs 324
- Exposure
- Cardiac resynchronization therapy (CRT) vs no CRT
- CRTn = 167
- Controln = 324reference
- Outcome
- Transplantation or death
Methodological detailsmulticentre, propensity-score matched, 5 quaternary referral centres
- Multicentre
- Propensity-score matched
- 5 quaternary referral centres
Main finding
As reported in the abstract
CRT vs ControlHazard ratio (95% CI)P value
Unadjusted Cox
0.40(0.25–0.64)
P < 0.001Multivariable Cox
0.44(0.28–0.71)
P = 0.001Observational data: associations, not effects.
Further findings
Systemic ventricular EF and QRS duration (longitudinal) · sustained to 5 years
- Significantly improved systemic ventricular EF with CRT
- P < 0.001
- Shorter QRS duration with CRT
- P = 0.015
Original publication
Multicenter Study of Survival Benefit of Cardiac Resynchronization Therapy in Pediatric and Congenital Heart Disease. JACC Clin Electrophysiol. Published 10 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →