Prevention & lipidsCase-control study
Multidimensional Aging Trajectories Preceding Cardiovascular Events
- Nested case-control study
- nested within the Aspirin in Reducing Events in the Elderly (ASPREE) cohort
- 4 controls matched per case by age, sex and education
- prospective follow-up
Authors' conclusion
Results of this nested case-control study show that declines in functional aging markers were prominent before clinically apparent CVD, suggesting that they may represent the culmination of progressive multisystem aging and indicating a prolonged window of opportunity for closer clinical evaluation and early intervention.
Study context
- Population
- Adults aged ≥70 years (≥65 for US racial and ethnic minoritized groups) without prior CVD event, dementia or significant physical disability, Australia and US, recruited 2010–2014
- Participants
- 12,015 adults
- Comparison
- CVD cases vs matched CVD-free controls
- Casesn = 2,403
- Controlsn = 9,612reference
- Outcome
- Trajectories of frailty (FI, Fried phenotype), intrinsic capacity (IC) and physical HRQOL preceding CVD events
- Follow-up
- 14 years
Main finding
As reported in the abstract
Rate of change in functional aging markers, cases vs controls
β
- frailty, FI
- 0.78 (95% CI 0.66–0.91)
- frailty, Fried
- 0.05 (95% CI 0.03–0.07)
- Intrinsic capacity (IC)
- −0.34 (95% CI −0.44 to −0.24)
- physical health-related quality of life (HRQOL)
- −0.55 (95% CI −0.70 to −0.40)
Observational data: associations, not effects.
Further findings
Components of the CVD composite
- Patterns broadly similar; divergence earlier for HF and fatal CHD (≥10 years before the event) than for MI or stroke
Original publication
Multidimensional Aging Trajectories Preceding Cardiovascular Events. JAMA Cardiol. Published 23 September 2026. doi:10.1001/jamacardio.2026.3597
Summarised from the published abstract; every number is checked against it