Heart failure & cardiomyopathiesCohort study
Multidimensional Social Adversity and Mortality in People With HIV Infection and Heart Failure: Insights From NYC Health + Hospitals HIV–Heart Failure Cohort
- Prospective cohort study
- multivariable adjusted
Authors' conclusion
SA was significantly associated with mortality and rehospitalization among people with HIV infection and heart failure, with domain-specific pathways influencing specific outcomes.
Study context
- Population
- People with HIV infection and HF, NYC Health + Hospitals HIV-Heart Failure (NYC 4H) cohort
- Exposure
- Social adversity vs no social adversity
- Any social adversity (SA)n = 601
- Economic hardshipn = 130
- Limited health care accessn = 155
- Unstable housingn = 129
- Social support challengen = 179
- Psychobehavioral instabilityn = 438
- Outcome
- All-cause, CV and infection-related mortality
- Follow-up
- Mean 3.8 years
Main finding
As reported in the abstract
Mortality, any SA vs none
Any SA vs Without SAHazard ratio (95% CI)
all-cause mortality
4.32(3.03–6.14)
CV mortality
4.05(2.17–6.83)
infection-related mortality
2.37(1.23–4.56)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| CV mortality, by SA domain — Social support challenge vs No SA | HR 2.19 (95% CI 1.35–3.55) | |
| CV mortality, by SA domain — Psychobehavioral instability vs No SA | HR 1.96 (95% CI 1.24–3.11) | |
| Infection-related mortality, by SA domain — Economic hardship vs No SA | HR 2.40 (95% CI 1.22–4.70) | |
| Infection-related mortality, by SA domain — Social support challenge vs No SA | HR 3.09 (95% CI 1.75–5.48) | |
| Rehospitalization, by SA domain · within 6 months — Neighborhood or built environment instability vs Without SA · 73% higher risk | adjusted OR 1.73 (95% CI 1.15–2.06) | |
| Rehospitalization, by SA domain · within 6 months — Psychobehavioral instability vs Without SA · 75% higher risk | adjusted OR 1.75 (95% CI 1.31–2.35) | |
| Rehospitalization, by SA domain · within 6 months — Social support challenge vs Without SA · 44% higher risk | adjusted OR 1.44 (95% CI 1.00–2.06) | |
| 0.20.5125Ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Multidimensional Social Adversity and Mortality in People With HIV Infection and Heart Failure: Insights From NYC Health + Hospitals HIV–Heart Failure Cohort. Circulation. Published 19 May 2026. doi:10.1161/circulationaha.126.078897
Summarised from the published abstract; every number is checked against it