Coronary disease & ACSRandomised controlled trial
Multidomain Rehabilitation for Older Patients with Myocardial Infarction
- Randomised controlled trial
- multicentre
- 2:1 randomisation
Authors' conclusion
Among older patients with impaired physical performance 1 month after myocardial infarction, a multidomain rehabilitation intervention resulted in a lower incidence of cardiovascular death or unplanned cardiovascular hospitalization within 1 year than usual care.
Study context
- Population
- Patients ≥65 years with impaired physical performance 1 month after MI, Italymedian age 80, 36% women
- Participants
- 512 patients
- Comparison
- Multidomain rehabilitation vs usual care
- Interventionn = 342
- Controln = 170reference
- Primary endpoint
- CV death or unplanned hospitalization for CV causes
- Follow-up
- 1 year
Primary result
As reported in the abstract
Hazard ratio
0.57
95% CI 0.36–0.89
P = 0.01
Events by treatment group
Intervention vs Control
HR 0.57 (95% CI 0.36–0.89); P = 0.01
Further findings
| Outcome | Intervention | Control | HR (95% CI) | |
|---|---|---|---|---|
| CV death | 4.1% | 5.9% | 0.69 (0.31–1.55) | |
| Unplanned hospitalization for CV causes | 9.1% | 17.6% | 0.48 (0.29–0.79) | |
| 0.20.5125Hazard ratio (log scale) |
Safety
- Serious adverse events associated with the intervention
- 0 · events
Serious adverse events associated with the intervention
- No serious adverse events associated with the intervention
Original publication
Multidomain Rehabilitation for Older Patients with Myocardial Infarction. N Engl J Med. Published 29 August 2025. doi:10.1056/nejmoa2502799
Summarised from the published abstract; every number is checked against it