Arrhythmias & electrophysiologyCohort study
Multielectrode catheter-based pulsed field ablation of persistent and long-standing persistent atrial fibrillation
- Observational cohort study
Authors' conclusion
In our cohort, PFA-based AF substrate ablation led to AF termination in 95.8% of cases. Very favourable clinical outcomes were observed during >1 year of follow-up.
Study context
- Population
- Patients with persistent atrial fibrillation (AF) >6 months or long-standing persistent AF undergoing first pulsed field ablation (PFA) (Farapulse) with a tailored multi-site left atrial (LA) ablation strategy
- Participants
- 72 patients
- Exposure
- PerAF > 6 m vs long-standing persistent AF (LSPAF)
Main finding
As reported in the abstract
AF termination with LA substrate ablation (Stage 1 and 2)
AF termination
95.8%
Observational data: associations, not effects.
Further findings
AF organized into left-sided atrial flutter
- Left atrial flutter (AFlu)
- 46 (74.2%)
- Left AFlu termination via PFA
- all cases
Procedural times
- Total procedural time
- 112 ± 25 min
- LA dwell time
- 59 ± 22 min
Single-procedure success · 14.9 ± 2.7 months
- Single-procedure success rate
- 74.6%
- AF-free survival
- 89.2%
Safety
Major complications
- Major complications
- 2 (2.8%)
Original publication
Multielectrode catheter-based pulsed field ablation of persistent and long-standing persistent atrial fibrillation. Europace. Published 1 October 2024. doi:10.1093/europace/euae246
Summarised from the published abstract; every number is checked against it