HypertensionRandomised controlled trial
Multifaceted Strategies for Hypertension Control in Low-Income Patients
- Cluster randomised controlled trial
- federally qualified health center clinics in Louisiana and Mississippi
Authors' conclusion
Among low-income patients with hypertension, a multifaceted, team-based implementation strategy resulted in a significantly greater reduction in systolic blood pressure than enhanced usual care.
Study context
- Population
- Low-income patients ≥40 years with uncontrolled hypertension at federally qualified health center clinics
- Participants
- 1,272 patients · 36 clinics
- Comparison
- Intervention vs Control
- Interventionn = 642
- Controln = 630reference
- Primary endpoint
- Mean change in SBP from baseline (primary effectiveness outcome)
- Follow-up
- 18 months
Primary result
Mean change in SBP from baseline
Between-group difference
−6.4 mm Hg
95% CI −9.0 to −3.8
P < 0.001
By group
Intervention
−15.5
mean change · 95% CI −17.4–-13.6 · mm Hg
Control
−9.1
mean change · 95% CI −11.0–-7.2 · mm Hg
Intervention vs Control
between-group difference −6.4 mm Hg (95% CI −9.0 to −3.8); P < 0.001
As reported in the abstract
Further findings
Mean
| Outcome | Intervention | Control | between-group difference (points) (95% CI) | P value | |
|---|---|---|---|---|---|
| Adherence summary score (0–4, higher = better adherence to BP management; primary implementation outcome) · over 18-month follow-up | 2.8 (95% CI 2.7–2.9) | 2.1 (95% CI 2.0–2.2) | 0.7 (0.6–0.8) | P < 0.001 | |
| −0.500.51Difference, points (linear scale) |
Safety
Serious adverse events
Original publication
Multifaceted Strategies for Hypertension Control in Low-Income Patients. N Engl J Med. Published 9 April 2026. doi:10.1056/nejmoa2504068
Summarised from the published abstract; every number is checked against it