Arrhythmias & electrophysiologyResearch article
Multimodality Imaging and Pace-Mapping Patterns in Patients With Cardiac Sarcoidosis and Ongoing Inflammation Undergoing Ventricular Tachycardia Ablation
- Study of patients with definite cardiac sarcoidosis (CS) and active inflammation referred for ventricular tachycardia (VT) ablation
Authors' conclusion
In patients with CS and active inflammation, most VT target sites were confined to LGE+ and FDG+ areas. VT exit sites were associated with FDG+ areas. Patients in whom only VT exit sites were identified had higher VT recurrences.
Study context
- Population
- Patients with definite cardiac sarcoidosis and active inflammation referred for VT ablation; PET and CMR findings registered to electroanatomic maps4 women, age 55 ± 11 years, ejection fraction 43% ± 14%
- Participants
- 14 patients
- Comparison
- Patients in whom only VT exit sites were identified vs patients in whom both nonexit sites and exit sites for individual VTs were identified
- only VT exit sites identifiedn = 6
- both nonexit sites and exit sites identifiedn = 8
Main finding
As reported in the abstract
VT target sites identified
distinct VTs
43
VT target sites
59
Further findings
VT recurrence · follow-up time of 32 ± 33 months · higher VT recurrence rate with only VT exit sites identified
P = 0.01
Location of VT target sites
- VT target sites in LGE+ areas
- 88%
- VT target sites in fluorodeoxyglucose (FDG)+ areas
- 71%
- LGE+ and FDG+ colocalized
- 59%
VT exit and nonexit sites
- VT exit sites
- 42 of 59
- nonexit sites
- 17 of 59
- VT exit sites were associated with FDG+ areas
Original publication
Multimodality Imaging and Pace-Mapping Patterns in Patients With Cardiac Sarcoidosis and Ongoing Inflammation Undergoing Ventricular Tachycardia Ablation. JACC Clin Electrophysiol. Published 11 September 2026. doi:10.1016/j.jacep.2026.07.020
Summarised from the published abstract; every number is checked against it