Coronary disease & ACSMechanistic study
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes
- Mechanistic study
- longitudinal
- multiomic factor analysis (MOFA)
- external validation cohort
Authors' conclusion
Hence, this study provides proof-of-concept evidence for the ability of MOFA to uncover multicellular immune programs in cardiovascular disease, opening new directions for mechanistic, biomarker and therapeutic studies.
Study context
- Population
- Patients with ACS or CCSplus external cohort n = 55
Main finding
As reported in the abstract
Multicellular immune signatures identified by MOFA
- Multicellular immune signatures characterized by distinct monocyte, natural killer and T cell substates and immune-communication pathways explain a large proportion of inter-patient variance
- Specific factors reflect disease state or associate with treatment outcome in ACS as measured using LVEF
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes. Nat Med. Published 21 May 2024. doi:10.1038/s41591-024-02953-4
Summarised from the published abstract; every number is checked against it