Heart failure & cardiomyopathiesCohort study
Multiorgan Physiological Deficits During Exercise Identify Clinical and Molecular Predisposition to Heart Failure With Preserved Ejection Fraction
- Cohort study with metabolomic and genomic analyses
- invasive cardiopulmonary exercise testing
- LASSO regression
- Multi-Ethnic Study of Atherosclerosis (MESA) validation cohort
- Genome-wide association study (GWAS) mapping
Authors' conclusion
Organ-specific responses to exercise and their circulating metabolite signatures are strongly linked to HFpEF development and prognosis.
Study context
- Population
- Heart failure with preserved ejection fraction (HFpEF) patients undergoing invasive cardiopulmonary exercise testing (iCPET); MESA participants (≈20-year follow-up)MESA
- Participants
- 6,345 patients
- Exposure
- ≥5 exercise deficits vs fewer; exercise-deficit metabolite signatures
Main finding
As reported in the abstract
Incident CV event or mortality (iCPET HFpEF cohort), by number of exercise deficits
Hazard ratio
3.90
95% CI 1.74–8.75
P < 0.0001
≥5 exercise deficits
HR 3.90 (95% CI 1.74–8.75); P < 0.0001
Observational data: associations, not effects.
Original publication
Multiorgan Physiological Deficits During Exercise Identify Clinical and Molecular Predisposition to Heart Failure With Preserved Ejection Fraction. Circulation. Published 7 April 2026. doi:10.1161/circulationaha.125.077579
Summarised from the published abstract; every number is checked against it