Heart failure & cardiomyopathies
A multiparametric heart failure score at baseline is associated with long-term outcome in patients with remotely monitored implantable cardioverter-defibrillators: A pooled analysis of 9 clinical trials
Pooled result · Death or WHFHResult — go to the resultAdjusted hazard ratio 2.05 95% CI 1.54–2.71Authors' conclusion
Based on a retrospective analysis of clinical trial data with adjudicated events, baseline HF Score derived from device-monitored variables was able to stratify patients at higher long-term risk of death or WHFH.
Study context
- Population
- ICD patients with preimplantation EF ≤35%, NYHA class II/III, no long-standing AF, remotely monitored (HeartInsight algorithm)
- Participants
- 1,841 patients · 9 clinical trials
- Comparison
- High vs low baseline heart failure (HF) Score
- Outcome
- Composite of:
- Death
- Worsening HF hospitalization (WHFH)
- Follow-up
- Median 631 days (IQR 385-865 days)
Methodological detailsretrospective, adjudicated events
- Retrospective
- Adjudicated events
Pooled result
Death or WHFH
Adjusted hazard ratio
2.05
95% CI 1.54–2.71
P < 0.0001
High HF Score vs Low HF Score
adjusted HR 2.05 (95% CI 1.54–2.71); P < 0.0001
As reported in the abstract
- Primary end point occurred (overall)
- 265 patients (14.4%)
Further pooled results
All-cause death · median follow-up 631 days
| Comparison | HR (CI) | P value | |
|---|---|---|---|
| High baseline HF Score | 2.37 (1.56–3.58) | P < 0.0001 | |
| 0.20.5125Hazard ratio (log scale) |
CV death · median follow-up 631 days
| Comparison | HR (CI) | P value | |
|---|---|---|---|
| High baseline HF Score | 2.19 (1.14–4.22) | P = 0.019 | |
| 0.20.5125Hazard ratio (log scale) |
WHFH · median follow-up 631 days
| Comparison | HR (CI) | P value | |
|---|---|---|---|
| High baseline HF Score | 1.91 (1.35–2.71) | P = 0.0003 | |
| 0.20.5125Hazard ratio (log scale) |
- All-cause death — Deaths, overall cohort
- 122 (6.6%)
- CV death — CV deaths, overall cohort
- 52 (42.6%) of deaths
- WHFH — worsening heart failure hospitalizations (WHFHs), overall cohort
- 243 WHFHs in 173 patients (9.4%)
Hierarchical outcome: all-cause death (highest priority), then repeated WHFHs
- Win ratio
- 2.47 (CI, 1.89-3.24; P < .0001)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A multiparametric heart failure score at baseline is associated with long-term outcome in patients with remotely monitored implantable cardioverter-defibrillators: A pooled analysis of 9 clinical trials. Heart Rhythm. Published 9 October 2024. doi:10.
Summarised from the published abstract; every number is checked against it