Heart failure & cardiomyopathies
Multipoint pacing is associated with reduction of heart failure hospitalizations or death in patients who do not respond to cardiac resynchronization therapy: results of the MORE-CRT multipoint pacing (MPP) randomized trial
Authors' conclusion
In the MORE-CRT MPP randomized trial, MPP was associated with a significant reduction of all-cause mortality and HF hospitalizations in prior non-responders to conventional biventricular pacing.
Study context
- Population
- Cardiac resynchronization therapy (CRT) non-responders (LV end-systolic volume relative reduction ≤15% after 6 months of biventricular pacing (BIVP))1,421 with complete data
- Participants
- 1,677 participants
- Comparison
- MPP vs BIVP in CRT non-responders
- MPPn = 722
- BIVPn = 699reference
- Primary endpoint
- HF hospitalizations or all-cause mortality
- Follow-up
- Mean 5 ± 1 months after randomization
Primary result
As reported in the abstract
RRR
36%
95% CI ±4%P = 0.0107
MPP
Odds ratio
0.60
P = 0.0124
multivariable analysis
Further findings
Heart failure (HF) hospitalizations or all-cause death, subgroups (e.g. ischaemic; interventricular electrical delay >105 ms)
- Lower with MPP vs BIVP in the whole population and in many subgroups
Original publication
Multipoint pacing is associated with reduction of heart failure hospitalizations or death in patients who do not respond to cardiac resynchronization therapy: results of the MORE-CRT MPP randomized trial. Europace. Published 30 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →