Heart failure & cardiomyopathiesSecondary analysis
Multipoint pacing is associated with improved prognosis and cardiac resynchronization therapy response: MORE-CRT multipoint pacing (MPP) randomized study secondary analyses
- Secondary analysis of the MORE-CRT MPP randomised trial
Authors' conclusion
In patients who do not respond to standard CRT despite the high BIV pacing percentage, MPP is associated with lower occurrence of HF hospitalizations and higher probability of reverse LV remodelling compared with BIV pacing.
Study context
- Population
- Cardiac resynchronization therapy (CRT) non-responders (LV end-systolic volume (LVESV) relative reduction <15% after 6 months of biventricular (BIV) pacing) with heart failure (HF), reduced EF and prolonged QRS, BIV pacing >97% before randomisation1,639 randomised
- Participants
- 593 participants
- Comparison
- MPP vs BIV pacing in CRT non-responders
- MPPn = 291
- BIVn = 302reference
- Primary endpoint
- Composite of freedom from cardiac death and HF hospitalizations and LVESV relative reduction ≥15%
- Follow-up
- 12 months
Primary result
As reported in the abstract
Hazard ratio
1.55
95% CI 1.02–2.34
P = 0.0402
Events by treatment group
MPP vs BIV
HR 1.55 (95% CI 1.02–2.34); P = 0.0402
Further findings
HF hospitalizations
IRR 50% · P = 0.0245
Reverse remodelling, dispersion of interventricular electrical delay >30 ms (subgroup)
P = 0.0335
- Reverse remodelling, dispersion of interventricular electrical delay >30 ms (subgroup): MPP n=51, BIV n=62
Original publication
Multipoint pacing is associated with improved prognosis and cardiac resynchronization therapy response: MORE-CRT MPP randomized study secondary analyses. Europace. Published 4 October 2024. doi:10.1093/europace/euae259
Summarised from the published abstract; every number is checked against it