Heart failure & cardiomyopathies
Musculoskeletal Co-Morbidities in Patients with Transthyretin Amyloid Cardiomyopathy: A Systematic Review
Authors' conclusion
The frequent association between ATTR-CM and carpal tunnel syndrome, ruptured biceps tendon, and lumbar spinal is confirmed, and the onset of these co-morbidities usually precedes the diagnosis of by years.
Study context
- Population
- Patients diagnosed with ATTR-CM, by any diagnostic method, with musculoskeletal co-morbidities22 studies
- Outcome
- Prevalence of musculoskeletal ATTR-deposition-related co-morbidities (carpal tunnel syndrome, ruptured biceps tendon, spinal stenosis, trigger finger)
Methodological detailsPRISMA guidelines, Risk of Bias Tool
- PRISMA guidelines
- Risk of Bias Tool
Pooled result
As reported in the abstract
Studies reporting musculoskeletal co-morbidities in ATTR-CM
Carpal tunnel syndrome reported
21 studies
Brachial biceps tendon rupture reported
3 studies
Spinal stenosis reported
8 studies
Further pooled results
Study quality (Risk of Bias Tool)
- All studies of high or moderate quality
Original publication
Musculoskeletal Co-Morbidities in Patients with Transthyretin Amyloid Cardiomyopathy: A Systematic Review. ESC Heart Fail. Published 21 December 2023. doi:10.
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