Coronary disease & ACSDiagnostic or prognostic study
Myocardial Blood Flow Quantification Using Stress Cardiac Magnetic Resonance Improves Detection of Coronary Artery Disease
- Diagnostic accuracy study
- multicentre
Authors' conclusion
This study demonstrates that sMBF and MPR using dual-sequence stress CMR can identify obCAD more accurately than qualitative analysis by experienced CMR readers.
Study context
- Population
- Individuals undergoing stress cardiovascular magnetic resonance (CMR); Obstructive coronary artery disease (obCAD) = stenosis ≥50% left main or ≥70% major vessel
- Participants
- 127 individuals
- Comparison
- Quantitative stress MBF (sMBF) and myocardial perfusion reserve (MPR) vs qualitative assessment of stress CMR
- Outcome
- Identification of obstructive CAD (obCAD)
Performance
As reported in the abstract
Detection of obCAD (AUC)
| Test or model | AUC | AUC (4 physicians, range) |
|---|---|---|
| Global sMBF | 0.90 (95% CI: 0.84-0.96) | |
| Global MPR | 0.86 (95% CI: 0.80-0.93) | |
| Qualitative assessment (QA) | 0.69–0.88 |
Further findings
| Outcome | Values | P value |
|---|---|---|
| Global sMBF, patient level | obCAD median 1.5 (IQR 1.2–1.8) mL/g/min · noCAD median 2.4 (IQR 2.1–2.7) mL/g/min | P < 0.001 |
| Global MPR, patient level | obCAD median 1.3 (IQR 1.0–1.6) · noCAD median 2.1 (IQR 1.6–2.7) | P < 0.001 |
sMBF and MPR, coronary artery level
- Significantly lower in vessels with obCAD than no obCAD (noCAD)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Myocardial Blood Flow Quantification Using Stress Cardiac Magnetic Resonance Improves Detection of Coronary Artery Disease. JACC Cardiovasc Imaging. Published 18 September 2024. doi:10.1016/j.jcmg.2024.07.023
Summarised from the published abstract; every number is checked against it