Heart failure & cardiomyopathies
Myocardial Flow Assessment After Heart Transplantation Using Dynamic Cadmium-Zinc-Telluride Single-Photon Emission Computed Tomography With 201 Tl and 99m Tc Tracers and Validated by 13 N-NH 3 Positron Emission Tomography
Authors' conclusion
This small study suggests that CZT SPECT using 201Tl and 99mTc tracers showed comparable MBF and MFR, and the results correlated well with those of 13 N-NH3 PET.
Study context
- Population
- Patients with prior heart transplantation undergoing cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) and 13 N-NH3 positron emission tomography (PET) dynamic scans; Cardiac allograft vasculopathy (CAV) assessment
- Participants
- 38 patients
- Comparison
- Dynamic CZT SPECT with 201Tl or 99mTc tracers vs 13 N-NH3 PET for myocardial blood flow (MBF) and myocardial flow reserve (MFR) quantification
- 99mTcn = 19
- Outcome
- Diagnostic performance for CAV (MBF and MFR quantification), validated by 13 N-NH3 PET
Performance
As reported in the abstract
Detection of PET MFR <2.0
| Strategy | AUC |
|---|---|
| 201Tl | 0.92 [0.71-0.99] |
| 99mTc | 0.87 [0.64-0.97] |
AUC
201Tl0.92 [0.71-0.99]
99mTc0.87 [0.64-0.97]
Further findings
| Outcome | 201Tl | 99mTc | PET | P value | |
|---|---|---|---|---|---|
| Correlation of CZT SPECT vs PET for stress MBF | correlation coefficient 0.95 | correlation coefficient 0.80 | Not reported in the abstract | P = 0.03 | PET: not reported in the abstract |
| Detection of angiographically defined moderate-to-severe CAV | |||||
| AUC | Not reported in the abstract | Not reported in the abstract | 0.86 [0.64-0.97] | 201Tl, 99mTc: not reported in the abstract |
- Detection of angiographically defined moderate-to-severe CAV: CZT SPECT AUC 0.90 [0.70-0.99]
- Detection of angiographically defined moderate-to-severe CAV: patients with angiography within 1 year of second scan
Correlation of CZT SPECT vs PET for stress MBF
- No significant difference between cohorts in correlation coefficients for other MBF and MFR values
Detection of angiographically defined moderate-to-severe CAV
- CZT SPECT comparable to 13 N-NH3 PET
Original publication
Myocardial Flow Assessment After Heart Transplantation Using Dynamic Cadmium-Zinc-Telluride Single-Photon Emission Computed Tomography With 201 Tl and 99m Tc Tracers and Validated by 13 N-NH 3 Positron Emission Tomography. Circ Cardiovasc Imaging. Published 14 June 2023. doi:10.
Summarised from the published abstract; every number is checked against it