Myocardial Flow Reserve, an Independent Prognostic Marker of All-Cause Mortality Assessed by 82 Rb PET Myocardial Perfusion Imaging: A Danish Multicenter Study
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.62 95% CI 1.31–2.02Authors' conclusion
MFR ≤2 predicts all-cause mortality independently of the extent of perfusion defects.
Study context
- Population
- Patients undergoing 82Rb PET myocardial perfusion imaging on suspicion of chronic coronary syndromes, Denmark39.0% with myocardial flow reserve (MFR) ≤2
- Participants
- 7,169 patients
- Exposure
- MFR ≤2 vs MFR >2
- Outcome
- All-cause mortality
- Follow-up
- Median 3.1 (IQR, 2.6-4.0) years
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
median 3.1 years
Hazard ratio
1.62
95% CI 1.31–2.02
P < 0.001
By group
MFR ≤2vs MFR >2
HR 1.62 (95% CI 1.31–2.02); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality, no reversible perfusion defects (subgroup, n=3101) | 1.86 (1.26–2.73) | P < 0.01 | |
| 0.20.5125Hazard ratio (log scale) |
All-cause mortality, by extent of perfusion defects (subgroups)
- MFR ≤2 associated with mortality across all subgroups
- all P<0.05
Cardiac and noncardiac death
- Prognostic value of impaired MFR similar for cardiac and noncardiac death
Original publication
Myocardial Flow Reserve, an Independent Prognostic Marker of All-Cause Mortality Assessed by 82 Rb PET Myocardial Perfusion Imaging: A Danish Multicenter Study. Circ Cardiovasc Imaging. Published 2 August 2023. doi:10.
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