Myocardial Strain Measurements Derived From MR Feature-Tracking

JACC Cardiovasc ImagingPublished 19 Jul 2023

Authors' conclusion

This study demonstrated the normal values of CMR-FT strain parameters in all 4 cardiac chambers in healthy subjects.

Study context

Population: Healthy adults with myocardial strain of all 4 chambers measured by cardiac magnetic resonance feature tracking (CMR-FT)
Participants: 3,359 adults · 44 studies

Outcome: Normal values (pooled means) of CMR-FT myocardial strain in all 4 cardiac chambers

As reported in the abstract

Pooled mean strain (CMR-FT), healthy adults

Left ventricular global longitudinal strain (LV-GLS) pooled mean: −18.4% (95% CI −19.2% to −17.6%)
LV global radial strain pooled mean: 43.7% (95% CI 40.0%-47.4%)
LV-GCS pooled mean: −21.4% (95% CI −22.3% to −20.6%)
LA-GLS total strain pooled mean: 34.9% (95% CI 29.6%-40.2%)
LA-GLS passive strain pooled mean: 21.3% (95% CI 16.6%-26.1%)
LA-GLS active strain pooled mean: 14.3% (95% CI 11.8%-16.8%)
RV-GLS pooled mean: −24.0% (95% CI −25.8% to −22.1%)
RA global longitudinal total strain pooled mean: 36.3% (95% CI 15.5%-57.0%)

Sources of heterogeneity (meta-regression)

LV-GLS: field strength (I2 = 98.6%): P < 0.001
LV-GLS: FT vendor (I2 = 98.5%): P < 0.001
LA-GLSactive: regional distribution (I2 = 97.3%): P < 0.001
LA-GLSactive: FT vendor (I2 = 97.4%): P < 0.001
LV-GCS: FT vendor (I2 = 98.8%): P = 0.02
RV-GLS: FT vendor (I2 = 93.8%): P = 0.01
Sex, age and MR vendor: no effect on normal values

Myocardial Strain Measurements Derived From MR Feature-Tracking. JACC Cardiovasc Imaging. Published 19 July 2023. doi:10.1016/j.jcmg.2023.05.019

Summarised from the published abstract; every number is checked against it