Heart failure & cardiomyopathies
Myocardial testosterone glucuronide and disease phenotypes in hypertrophic cardiomyopathy
Main finding · Signal for m/z 463.23 (testosterone glucuronide)Result — go to the resultFold higher signal 3.3Authors' conclusion
DESI-IMS revealed selective accumulation of testosterone glucuronide in hypertrophied myocardium from patients needing SRT, suggesting that androgen-linked metabolic remodelling plays a role in advanced obstructive physiology in HCM.
Study context
- Population
- Patients with hypertrophic cardiomyopathy (HCM) undergoing either right-ventricular biopsy or surgical septal myectomypatients analysed, 34 [55.7%] female, mean age 64.5 ± 15.9 years, 43 (70.5%) obstructive HCM
- Participants
- 61 patients
- Exposure
- Myocardial lipid signatures by desorption electrospray ionization imaging mass spectrometry (DESI-IMS) in patients who required SRT vs those who did not
- SRTn = 20
- non-SRTn = 41
- Outcome
- Signal for m/z 463.23 (testosterone glucuronide)
Main finding
As reported in the abstract
Fold higher signal
3.3
P < 0.001
Observational data: associations, not effects.
Further findings
Predictor of elevated testosterone-glucuronide intensity (confirmatory regression)
- SRT β
- 1.991
- P
- P = 0.004
- SRT remained the only predictor
- Adjusted for age at diagnosis and the presence of hypertension
Original publication
Myocardial testosterone glucuronide and disease phenotypes in hypertrophic cardiomyopathy. ESC Heart Fail. Published 16 January 2026. doi:10.
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