Myocardial Tissue-Level Characteristics of Adults With Metabolically Healthy Obesity
Authors' conclusion
This study provides the first evidence of subclinical myocardial tissue-level remodeling in adults with obesity, regardless of metabolic health.
Study context
- Population
- Obese nondiabetic adults without cardiac symptoms undergoing CMR
- Participants
- 120 adults
- Exposure
- Metabolically healthy obesity (MHO) vs metabolically healthy controls without obesity vs metabolically unhealthy obesity (MUHO)
- MHOn = 32
- Healthy controlsn = 32reference
- MUHOn = 56
- Outcome
- Myocardial tissue-level characteristics (ECV, native T2) as indicators of myocardial fibrosis and edema
Methodological detailsregistry, 3-centre, cardiac imaging study
- Registry
- 3-centre
- Cardiac imaging study
Main finding
As reported in the abstract
- MHO vs Healthy controls: P < 0.001
- MUHO vs MHO: P = 0.002
Observational data: associations, not effects.
Further findings
Myocardial fibrosis, independent risk factor (multivariate regression)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Increased body mass indexIndependent risk factor for myocardial fibrosis · multivariate regression analysis | 6.28 (3.17–12.47) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
LVEF
- No intergroup difference in LVEF
Global longitudinal peak systolic strain and early diastolic longitudinal strain rate
- Reduced in MHO, indicating subclinical systolic and diastolic dysfunction
Original publication
Myocardial Tissue-Level Characteristics of Adults With Metabolically Healthy Obesity. JACC Cardiovasc Imaging. Published 12 April 2023. doi:10.
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