Heart failure & cardiomyopathies
Myosin ATPase Inhibition Relieves the Energetic Burden in Skeletal Myofibres of Patients With Heart Failure With Reduced Ejection Fraction
Authors' conclusion
Skeletal muscle myosin becomes inefficient in HFrEF. Pharmacological inhibition of myosin ATPase activity offers an inventive strategy to lower muscle energy demand and potentially address metabolic disturbances in HFrEF.
Study context
- Population
- Patients with heart failure with reduced ejection fraction (HFrEF) and controls with comparable age, sex, and body mass index (skeletal muscle tissue)patients with HFrEF 11 · controls 10
- Participants
- 11 vs 10
- Comparison
- HFrEF vs controls
- HFrEFn = 11
- Controlsn = 10
- Outcome
- Acetyl-lysine sites and myosin energy consumption in resting muscle fibers
Methodological details2′-(or-3′)-O-(N-Methylanthraniloyl) adenosine 5′-triphosphate chase experiments, LC/MS-based proteomics profiling
- 2′-(or-3′)-O-(N-Methylanthraniloyl) adenosine 5′-triphosphate chase experiments
- LC/MS-based proteomics profiling
Main finding
As reported in the abstract
- Distinct regulation of acetyl-lysine sites and higher myosin energy consumption in resting muscle fibers from patients with HFrEF than in controls
Further findings
Myosin ATP consumption with mavacamten
- Dose-dependent reduction in myosin ATP consumption in myofibres of patients with HFrEF, reversing the pathological over-consumption
Original publication
Myosin ATPase Inhibition Relieves the Energetic Burden in Skeletal Myofibres of Patients With Heart Failure With Reduced Ejection Fraction. Circ Heart Fail. Published 6 May 2026. doi:10.
Summarised from the published abstract; every number is checked against it