Coronary disease & ACSResearch article
N-of-1 Trial of Angina Verification Before Percutaneous Coronary Intervention
- N-of-1 placebo-controlled study
- multicentre
- n-of-1
Authors' conclusion
Similarity score powerfully predicted symptom improvement from PCI.
Study context
- Population
- Patients undergoing single-vessel percutaneous coronary intervention (PCI) for stable symptoms
- Participants
- 51 patients
- Comparison
- Balloon occlusion vs Placebo inflation
- Outcome
- Ability of the similarity score to predict symptom relief with PCI
Main finding
As reported in the abstract
Lower angina frequency at follow-up, by similarity score · follow-up
Upper quartile similarity score (5.25): OR
8.01 (95% CrI 2.39-15.86)
Lower quartile similarity score (0.875): OR
1.31 (95% CrI 0.71-1.99)
Pr(difference)
>99.9%
Median similarity score (Q1-Q3: 0.875-5.25)
3
Original publication
N-of-1 Trial of Angina Verification Before Percutaneous Coronary Intervention. J Am Coll Cardiol. Published 14 May 2024. doi:10.1016/j.jacc.2024.04.001
Summarised from the published abstract; every number is checked against it