Heart failure & cardiomyopathies
Natriuretic Peptide Cut Points for Heart Failure Classification in Individuals With and Without Obesity
Authors' conclusion
The application of a single NP cut point resulted in fewer individuals with obesity being up-classified to stage B HF compared with normal-weight individuals.
Study context
- Population
- Participants free of heart failure (HF) from community-based cohorts
- Participants
- 32,735 participants5 cohorts
- Comparison
- Up-classification to stage B HF by natriuretic peptide (NP) criterion, by obesity class
- Outcome
- Proportion up-classified to stage B HF using the NP criterion (2022 vs 2013 guidelines)
Methodological details5 community-based cohorts
- 5 community-based cohorts
Pooled result
As reported in the abstract
Up-classified to stage B HF by NP criterion
Further pooled results
- Optimal NT-proBNP cut point to predict future HF — Normal weight
- 109 (95% CI 80–157) pg/mL
- Optimal NT-proBNP cut point to predict future HF: Obesity 80 (95% CI 53–121) pg/mL
Incident HF · median follow-up 13 years
- HF events
- 3077
- Higher NP and BMI each associated with greater HF risk
- P < 0.0001
- BMI modified the NP–HF association: higher NP associated with greater HF risk at lower BMI
Original publication
Natriuretic Peptide Cut Points for Heart Failure Classification in Individuals With and Without Obesity. Circ Heart Fail. Published 20 August 2025. doi:10.
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