Heart failure & cardiomyopathies
Natriuretic Peptide Normative Levels and Deficiency: The National Health and Nutrition Examination Survey
Authors' conclusion
This study establishes the normative NP concentrations across the lifespan of a healthy United States population.
Study context
- Population
- Healthy US participants with NT-proBNP measurements, NHANES 1999–2004
- Participants
- 18,145 participants
- Exposure
- NT-proBNP concentrations by sex and by race and ethnicity
- Outcome
- Reference range of NT-proBNP and prevalence of NP deficiency (<2.5th percentile)
Methodological detailsnationally representative, weighted multivariable-adjusted linear regression
- Nationally representative
- Weighted multivariable-adjusted linear regression
Main finding
As reported in the abstract
Adjusted % difference in NT-proBNP concentrations
Adjusted percentage difference (95% CI)
Females vs Males1-10 years; similar
4.2%(−3.3% to 12.2%)
Females vs Males20-30 years; highest
150.5%(123.5%–180.8%)
Non-Hispanic Black vs Non-Hispanic White1- to 10-years; lower
19.6%(10.7%–27.6%)
Non-Hispanic Black vs Non-Hispanic White30-40 years; lower, most pronounced
40.2%(33.7%–46.0%)
- Estimated US individuals with NP deficiency
- 9.1 million
Observational data: associations, not effects.
Further findings
Cardiometabolic disease with NP deficiency
- NP deficiency associated with higher risk of hypertension, dyslipidemia, obesity and insulin resistance
Original publication
Natriuretic Peptide Normative Levels and Deficiency: The National Health and Nutrition Examination Survey. JACC Heart Fail. Published 27 September 2023. doi:10.
Summarised from the published abstract; every number is checked against it