Heart failure & cardiomyopathiesCohort study
Natural History of Patients With Histologically Proven Acute Eosinophilic Myocarditis
- Retrospective cohort study
- international
- multicenter
Authors' conclusion
Acute EM can often present without peripheral eosinophilia, and rates of in-hospital and midterm mortality or HTx are high.
Study context
- Population
- Patients with histologically proven acute eosinophilic myocarditis (EM), 53 centres, 1992–2023193 screened
- Participants
- 156 patients
Main finding
As reported in the abstract
In-hospital death or HTx
In-hospital death or HTx (22 deaths, 1 HTx)
23 patients (14.7%)
Estimated death or HTx at 1 year
19.0%
Estimated death or HTx at 3 years
23.8%
Peripheral eosinophilia reported
57.4%
Observational data: associations, not effects.
Further findings
Death or HTx by EM form · 3 years · nonsignificant
P = 0.15
Baseline characteristics · presentation
- Median age (first to third quartile 34-59 years)
- 48 years
- Male
- 67.3%
- Median LVEF (first to third quartile 25%-48%)
- 32%
- Dyspnea
- 75.6%
- Fever
- 61.3%
- Chest pain
- 53.2%
Associated disorders
- Eosinophilic granulomatosis with polyangiitis
- 22.4%
- Hypersensitivity forms
- 14.1%
- Idiopathic/undefined forms
- 44.9%
- Miscellaneous causes
- 18.6%
Original publication
Natural History of Patients With Histologically Proven Acute Eosinophilic Myocarditis. Circulation. Published 6 February 2026. doi:10.1161/circulationaha.125.074797
Summarised from the published abstract; every number is checked against it