Congenital heart diseaseSecondary analysis
Neonatal Cerebrovascular Stability Index and Oxygenation With 3-Month Neurodevelopmental Outcomes
- secondary analysis of a longitudinal cohort study
Authors' conclusion
Neonatal CSI and rcSO2 associated with 3-month cognitive and motor outcomes in CHD and CHD subgroups, and groups differed in their directional associations. Future studies should explore CSI as an indicator of risk for developmental delays in CHD.
Study context
- Population
- Congenital heart disease (CHD) and control infantscontrol 41 · CHD 29
- Participants
- 70 infants
- Comparison
- associations of neonatal cerebrovascular stability index (CSI) and rcSO2 with 3-month neurodevelopmental outcomes (NDOs) within CHD and control groups and within CHD subgroups; group and subgroup differences in these associations
- CHDn = 29
- controln = 41
Primary result
As reported in the abstract
Cognitive scores (Bayley-III) with CSI and rcSO2 in CHD infants · 3-month
CSI associated with cognitive scores in CHD
P = 0.03
rcSO2 associated with cognitive scores in CHD
P = 0.02
Further findings
Motor scores with CSI, CHD vs controls · 3-month
- CSI positively associated with motor scores in CHD, did not associate in controls
- P = 0.02
Cognitive scores with rcSO2, CHD vs controls · 3-month
- rcSO2 positively associated with cognitive scores in CHD, negatively associated in controls
- P = 0.01
Language scores with rcSO2 (biventricular subgroup) · 3-month
- rcSO2 associated with language scores in the biventricular subgroup
- P = 0.01
Motor and cognitive scores (cyanotic subgroup) · 3-month
- CSI associated with motor scores in the cyanotic subgroup
- P = 0.04
- rcSO2 associated with cognitive scores in the cyanotic subgroup
- P = 0.01
Original publication
Neonatal Cerebrovascular Stability Index and Oxygenation With 3-Month Neurodevelopmental Outcomes. JACC Adv. Published 22 April 2026. doi:10.1016/j.jacadv.2026.102761
Summarised from the published abstract; every number is checked against it