Congenital heart diseaseMeta-analysis
Neuroimaging and Neurodevelopmental Outcomes Among Individuals With Complex Congenital Heart Disease
- Systematic review
- Six databases searched
Study context
- Population
- Individuals with transposition of great arteries or single-ventricle congenital heart disease (CHD)45 papers · 25 studies
- Outcome
- Associations between neuroimaging and neurodevelopmental, neurocognitive, psychiatric or behavioral outcomes
Pooled result
As reported in the abstract
- Structural brain injury generally linked to poorer neurodevelopment in infancy
- Brain volumes and microstructural and functional brain changes appear linked to neurocognitive outcomes (attention, learning, memory, executive function deficits) in children and adolescents
- Fetal neuroimaging studies were limited
Further pooled results
Psychiatric outcomes
- Papers investigating psychiatric outcomes
- 4
- None found associations with neuroimaging
Original publication
Neuroimaging and Neurodevelopmental Outcomes Among Individuals With Complex Congenital Heart Disease. J Am Coll Cardiol. Published 5 December 2023. doi:10.1016/j.jacc.2023.09.824
Summarised from the published abstract; every number is checked against it