Neurological Injury and Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction
Authors' conclusion
Significant brain abnormalities are commonly present in patients with a single ventricle, and detection of these lesions increases as children progress through staged surgical reconstruction, with multiple coexisting lesions more common earlier than later.
Study context
- Population
- Patients with a single ventricle undergoing staged surgical reconstructionscans in 168 subjects
- Participants
- 235 patients
- Exposure
- Pre-BDG vs BDG vs post-Fontan stages
- Pre-BDGn = 63reference
- BDGn = 118
- Fontann = 54
- Outcome
- Brain abnormalities on MRI by surgical stage
Methodological detailsserial MRI across surgical stages
- Serial MRI across surgical stages
Main finding
As reported in the abstract
Nonacute ischemic white matter changes, focal tissue loss and ventriculomegaly more common in BDG and Fontan vs pre-BDG
P<0.05
Odds of brain injury (adjusted for surgical stage) decreased with increasing cerebral blood flow
63%-75%
Odds of ≥2 coexisting lesions decreased with increasing cerebral blood flow
44%
Observational data: associations, not effects.
Original publication
Neurological Injury and Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction. Circulation. Published 28 December 2016. doi:10.
Summarised from the published abstract; every number is checked against it