Arrhythmias & electrophysiology

New technique to achieve total mitral isthmus block: Targeting masked epicardial conductions

Heart RhythmPublished Prospective single-group study

Authors' conclusion

After MI block, an additional pacing maneuver from the LLR up to the roof unmasked EC in 32% of patients. Targeting these conductions achieved total MI block in 94% of patients.

Study context

Population
Patients ablated for persistent AF with successful pulmonary vein isolation, roof line block and mitral isthmus block
Participants
50 patients
Outcome
Prevalence of masked epicardial conduction after mitral isthmus block, and feasibility of targeting it by radiofrequency ablation
Methodological detailsconsecutive patients
  • Consecutive patients

Main finding

As reported in the abstract

Masked epicardial conduction unmasked by pacing from the left lateral ridge up to the roof

16 of 50 patients

32%

Success of additional ablation to isolate epicardial conduction

81.3%

13/16

Overall total isthmus block

47/50 patients

94%

Observational data: associations, not effects.

Safety

No complications reported

Original publication

New technique to achieve total mitral isthmus block: Targeting masked epicardial conductions. Heart Rhythm. Published 27 November 2025. doi:10.1016/j.hrthm.2025.11.045

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