Valvular & structural heart diseaseCohort study
New Threshold for Defining Mild Aortic Stenosis Derived From Velocity-Encoded MRI in 60,000 Individuals
- Cohort study
- deep learning model
- external validation cohort
Authors' conclusion
Mild AS, as defined by the proposed criteria, was linked to adverse outcomes in the UK Biobank and in NEDA.
Study context
- Population
- UK Biobank participants with velocity-encoded CMR; external validation in NEDA clinical echo cohortUK Biobank
- Participants
- 62,902 participants
- Exposure
- Mild ASproposed vs no aortic stenosis (AS)
- mild ASproposedn = 3,676
Main finding
As reported in the abstract
Prevalence of mild ASproposed and subsequent AV replacement
Mild ASproposed
5.8%
3,676 of 3,676
- Mild ASproposed
- HR 31.7; P < 0.001
- Moderate AS
- HR 522.4; P < 0.001
- Severe AS
- HR 3,057.4; P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality (NEDA, echo-defined mild ASproposed, n = 101,335) | 1.25 (1.24–1.27) | ||
| 0.512Hazard ratio (log scale) |
| Outcome | HR | P value |
|---|---|---|
| AF · mean 3.9 years · 110 events | 1.86 | P = 1.4 × 10-9 |
| HF · mean 3.9 years · 70 events | 2.37 | P = 5.9 × 10-11 |
Original publication
New Threshold for Defining Mild Aortic Stenosis Derived From Velocity-Encoded MRI in 60,000 Individuals. J Am Coll Cardiol. Published 8 April 2025. doi:10.1016/j.jacc.2025.01.035
Summarised from the published abstract; every number is checked against it