Cardiometabolic & kidneyCohort study
Nocturnal hypoxaemic burden is associated with incident major adverse cardiovascular events in patients with type 2 diabetes
- Prospective cohort study
- sleep-disordered breathing sub-study of DIACORE
Authors' conclusion
In the present study, NHB was associated with MACE in patients with T2D and can be easily measured using oximetry.
Study context
- Population
- Patients with T2DM in a German cohort (DIACORE) with overnight oximetry
- Participants
- 1,255 patients
- Exposure
- Highest quartile vs quartiles 1–3 of nocturnal hypoxaemic burden
- Outcome
- Incident MACE:
- MI
- Stroke
- CV death
- Follow-up
- Median 6.5 years
Main finding
Incident MACE by T90
Adjusted hazard ratio
1.48
95% CI 1.04–2.12
P = 0.032
Q4 vs Q1-3
adjusted HR 1.48 (95% CI 1.04–2.12); P = 0.032
As reported in the abstract
- Major adverse cardiovascular events (MACE) occurred (overall)
- 149 (12%)
Observational data: associations, not effects.
Further findings
| Outcome | adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Incident MACE by T90non-specific · T90non-specific | 1.62 (1.14–2.30) | P = 0.007 | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Nocturnal hypoxaemic burden is associated with incident major adverse cardiovascular events in patients with type 2 diabetes. Eur J Prev Cardiol. Published 28 April 2025. doi:10.1093/eurjpc/zwaf259
Summarised from the published abstract; every number is checked against it