Heart failure & cardiomyopathiesCohort study
Non-dilated left ventricular cardiomyopathy in patients with chronic Chagas disease and heart failure with reduced left ventricular ejection fraction
- Cohort of all patients with chronic Chagas disease (CChD) followed at our institution
- single institution
- January 2000 to January 2010
Authors' conclusion
Non-dilated left ventricular cardiomyopathy affects one in 10 patients with CHF due to CChD, and the 5-year survival rate is 59%.
Study context
- Population
- Patients with chronic Chagas disease (CChD) and heart failure with reduced left ventricular ejection fractionpatients with CChD, 21 (10%) had non-dilated left ventricular cardiomyopathy (NDLVC) · NDLVC 21
- Participants
- 215 patients
- Exposure
- NDLVC vs dilated cardiomyopathy (DCM) secondary to CChD
- NDLVCn = 21
Main finding
As reported in the abstract
Baseline characteristics of NDLVC group
| Group | mean age | male | median daily dose of metoprolol | Left ventricular diastolic diameter (LVDD) | Left ventricular ejection fraction (LVEF) | Segmental wall motion abnormalities (SWMA) |
|---|---|---|---|---|---|---|
| NDLVC | 62 ± 9 years | 12 (57%) | 100 (62, 5, 125) mg | 51 ± 29 mm | 39 ± 6.4% | 12 (57%) |
Observational data: associations, not effects.
Further findings
Predictor of all-cause mortality for patients with NDLVC (Cox regression)
| Comparison | hazard ratio (95% CI) | P value | |
|---|---|---|---|
| Beta-blocker therapy · only independent predictor | 0.16 (0.04–0.68) | P = 0.01 | |
| 0.050.21520Hazard ratio (log scale) |
| Outcome | NDLVC | DCM | Estimate | P value |
|---|---|---|---|---|
| Kaplan-Meier survival estimates at 12, 24, 36, 48, and 60 months · 60-month follow-up | 71%, 71%, 59%, 59%, and 59% | 77%, 61%, 49%, 38%, and 30% | P = 0.04 |
- All-cause mortality in NDLVC · Mean follow-up 50.8 ± 3.8 months
- 43% · 9 of 21
Original publication
Non-dilated left ventricular cardiomyopathy in patients with chronic Chagas disease and heart failure with reduced left ventricular ejection fraction. ESC Heart Fail. Published 13 January 2026. doi:10.1093/eschf/xvag020
Summarised from the published abstract; every number is checked against it